Stem Cells Show Promise for Helping Alzheimer’s Disease with Neurodegenerative Disease via Multiple Mechanisms

Stem Cells Show Promise for Helping Alzheimer’s Disease with Neurodegenerative Disease via Multiple Mechanisms

Alzheimer’s disease is the most common form of dementia, and though its prevalence is growing, there are currently no medical interventions that are able to reverse or slow the disease. Most current therapies address the symptoms of Alzheimer’s disease rather than the underlying cause of the disease.

Stem cells appear to offer a promising opportunity for treating Alzheimer’s disease and other neurodegenerative disorders, and a recent review published in Current Alzheimer Research has covered research into the ways stem cells can be applied to these disorders. Specifically, the authors of the review discuss the stem cell sources that may offer the potential to treat neurodegenerative diseases and the mechanisms by which these stem cells may confer benefits to this set of patients.

According to data collected so far, stem cells may be both safe and effective in treating neurodegenerative disorders like Alzheimer’s disease, but the mechanism by which they produce benefits for those with these disorders is not entirely clear. There are some data that show that the replacement of degenerated tissue with new proliferative stem cells accounts for stem cell benefits in models of neurodegenerative disorders, while other data show that stem cells can lead to advantageous enhancements in the expression of synaptic proteins.

Evidence from other studies, however, suggest that stem cells help with neurodegenerative disease through the release of neurotrophic factors that lead to paracrine benefits. Additional studies point to modulation of the immune system as the way that stem cells may help those with neurodegenerative disorders.

Future research will help to elucidate the specific mechanisms by which stem cells can provide effective therapy for people with neurodegenerative disorders. It may be the case that a variety of stem cell types used in multiple ways can be helpful for neurodegenerative disease therapy, and research will help to delineate the different ways stem cells can be used and inform the therapies that are developed.

 

Reference: Bali, P, et al. (2017). Potential for stem cells therapy in Alzheimer’s disease: Do neurotrophic factors play a critical role? Current Alzheimer Research, 14(2), 208-220.

Hyperbaric Oxygen Therapy for Alzheimer’s Disease

Hyperbaric Oxygen Therapy for Alzheimer’s Disease

Alzheimer’s disease causes patients to have difficulty recalling memories and performing tasks. Alzheimer’s disease is progressive, which means it gets worse over time. Once Alzheimer’s disease begins, patients either stay the same or get worse. Most people notice symptoms getting worse over a period of 10 years. However, some people with Alzheimer’s disease will get worse very rapidly, over the course of a few years.

Because Alzheimer’s disease is discussed frequently in popular media, many people know that part of the disease process is the accumulation of abnormal proteins in the brain, namely beta-amyloid plaques and tau neurofibrillary tangles. One less well-known effect of Alzheimer’s disease is that it interferes with blood flow in the brain. This decreased blood flow is so common, in fact, that doctors can detect low brain activity using positron emission tomography (PET), which can help make the diagnosis of Alzheimer’s disease.

Between 2002 and 2012, researchers tested 244 treatments for Alzheimer’s disease, and only one medication was approved by the FDA. After all this time, there is still no cure for Alzheimer’s disease. In fact, the drugs used to treat Alzheimer’s disease are mostly ineffective. At best, they slow the progression of the disease for several months to a few years.

This lack of success has prompted several research groups to focus on other treatments for Alzheimer’s disease. One experimental treatment for Alzheimer’s disease is hyperbaric oxygen therapy. In hyperbaric oxygen therapy, patients rest in a specialized chamber while they experience oxygen at a slightly higher pressure than they would in the outside world.

Researchers wanted to determine whether hyperbaric oxygen therapy could improve the symptoms of Alzheimer’s disease, but also whether they could see those brain changes using PET. To do this, Drs. Harch and Fogarty enrolled a woman with rapidly deteriorating Alzheimer’s disease in their clinical study. She was exhibiting the characteristic signs of Alzheimer’s disease and reduced brain activity and blood flow in her brain. They treated her with a series of hyperbaric oxygen therapy treatments (1.15 atmospheres, 40 minutes, 5 days per week over 66 days).

After 21 treatments, the woman had increased energy, her mood was better, she was better able to perform activities of daily living, and she was actually performing crossword puzzles. After 40 hyperbaric oxygen treatments, she had better memory and concentration, she was sleeping better, her appetite had improved, she was able to hold conversations and able to use a computer.

Interestingly, when the researchers performed follow-up PET study after hyperbaric oxygen therapy, blood flow and brain activity improved as much as 38% compared to the PET study before treatment.

Additional clinical studies with larger groups of Alzheimer’s disease patients are needed to determine how effective hyperbaric oxygen therapy is, what pressure to use, and how many treatments are needed, etc. Nonetheless, the impressive changes reported in this case study are promising, and should spark additional clinical research.

Contact a Stemedix Care Coordinator for more information on Regenerative Medince Therapy combined with Hyperbaric Oxygen Therapy (HBOT) for Alzheimer’s Disease.

Reference: Harch et al. (2019). Hyperbaric oxygen therapy for Alzheimer’s dementia with positron emission tomography imaging: a case report. Medical Gas Research. 2019 Jan 9;8(4):181-184.

What Effects Do Pain Killers Have on Dementia?

What Effects Do Pain Killers Have on Dementia?

For years, medical experts have warned of the medical concerns associated with opioids, including depression, weakened immune system, and digestive issues. Now, however, new research shows that they could be particularly dangerous for dementia patients.

The Dangers of Painkillers for Dementia Patients

According to research presented at the Alzheimer’s Association International Conference, opioid-based painkillers can triple the side effects of dementia. Individuals taking the drugs experienced more pronounced personality changes, significant increases in confusion and sedation, and lower activity levels throughout the day.

In another study, researchers focused exclusively on known as “Z drugs,” which are currently given to hundreds of thousands of patients with dementia to promote sleep. Drugs under this category included zolpidem, zopiclone, and zaleplon. Findings revealed that patients on these drugs faced an increased risk of bone fracture, which contributes to an increased risk of death in people with dementia.

A Widespread Problem

Alzheimer’s, which is the most common form of dementia, currently affects an estimated 5.7 million Americans. Roughly half of the people living in care homes and suffering from this or another form of dementia experience pain to some degree, which can result from unrelated medical conditions such as arthritis. Unfortunately, as dementia patients face compounding communication challenges, treating their pain can become more difficult.

The study has prompted experts to explore other, non-pharmaceutical means of treating pain and sleep disorders in dementia patients. Alzheimer’s research group leaders believe that the solution lies in finding nondrug interventions to help manage pain and promote quality of life while minimizing serious side effects like those revealed by the study findings. Regenerative therapy may be an option to consider for those battling Alzheimer’s disease or dementia.

Alzheimer’s & Dementia: What Are the Differences?

Alzheimer’s & Dementia: What Are the Differences?

Alzheimer’s and dementia are two terms that are often used interchangeably, but there are actually key differences among them. While the former refers to a condition, the latter is an all-encompassing term used to describe a series of symptoms. Here, we take a closer look at the differences between Alzheimer’s disease and dementia to cultivate a better understanding of the terms.

Dementia: A Series of Symptoms

Dementia is often referred to as an “umbrella term” which refers to a number of different symptoms. In broad terms, these symptoms affect an individual’s ability to perform daily tasks independently. More specifically, the symptoms can include behavioral changes, declining memory, altered thinking or reasoning skills, and reduced focus.

Alzheimer’s is one condition which contributes to dementia, but it is not the only condition linked to this set of symptoms. In fact, it’s possible for people to suffer from more than one type of dementia, and more than 47 million people are affected by it worldwide. There are other types and causes of dementia, such as Huntington’s disease, Parkinson’s disease, and Creutzfeldt-Jakob disease.

Alzheimer’s: A Specific Condition

One of the simplest ways to remember the difference between Alzheimer’s and dementia is to think of Alzheimer’s as a condition, while dementia is a syndrome. Alzheimer’s is responsible for between 60-80% of all dementia cases, making it the most common form of dementia.

Alzheimer’s is progressive, meaning it worsens over time. It destroys the memory as well as other critical mental functions, which is why patients often experience significant personality changes over time. A decline in social and intellectual skills also impacts the condition’s sufferers. While the majority of individuals with Alzheimer’s disease are 65 and older, an estimated 200,000 Americans are younger than 65 and suffer from early-onset Alzheimer’s.

Although there is currently no known cure for this condition, it is still possible for individuals who have been diagnosed to enjoy a high quality of life. Implementing lifestyle changes and enlisting the help of specialists are among the best ways to proactively manage Alzheimer’s or any other form of dementia.

Daily Tips for Living with Alzheimer’s

Daily Tips for Living with Alzheimer’s

Whether you have been recently diagnosed with Alzheimer’s disease or you’re caring for someone with the condition, maintaining a high quality of life often means adjusting daily routines. While the precise types of adjustments needed will vary at different points in time, one way to manage stressors is to find coping strategies that effectively alleviate each challenge as it arises. Here, we explore some daily living tips you or your family members may find helpful.

Create & Follow a Daily Routine

Sticking to a routine can help ensure daily tasks get accomplished. It may help to follow a written plan each day. Also, many Alzheimer’s patients find that important appointments and other key tasks are best scheduled in the morning, when alertness is at its peak.

Focus on One Task at a Time

The Mayo Clinic explains that reducing distractions can help individuals improve their focus. Instead of doing housework while talking on the phone, for instance, devoting attention to one activity at a time may make it easier to concentrate.

Connect with Others

Socializing doesn’t just improve mood; it can also support mental health. According to a study conducted by the University of Michigan, even just ten minutes of social interaction can boost cognitive performance. Make a point to share meals with others, see friends, or stay active in the community to get plenty of interaction with others.

Find a Support System

Whether it’s church, a group that meets in person, or an online, there are many outlets for people living with Alzheimer’s to go for support. Family, friends, and even pets can also be sources of strength on particularly challenging days.

Recognize Triggers

Pinpoint any stressors that trigger anxiety or other negative feelings and find ways to actively avoid them. For instance, if feeling rushed leads to frustration, make sure others know that you need more time.

Keep Your Doctor’s Appointments

Attending doctor’s appointments can be difficult with transportation challenges, but according to the Alzheimer’s Association, doctors play a critical role in helping both patients and their families. Thus, it’s important to maintain scheduled visits whenever possible. Physicians and specialists can help patients select optimal medication for specific symptoms, recommend tailored disease management strategies, and provide treatment for any coexisting conditions. They may also have information about local clinical studies, which are becoming more prevalent as a result of accelerating research progress.

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